Jiazheng Wang1, Alan Wright1, De-en Hu1, Richard Hesketh1, and Kevin M. Brindle1,2
1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 2Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
We
have developed a single-shot 3D sequence for hyperpolarized 13C MRI,
with a spatial-spectral (SpSp) pulse for excitation and a stack-of-spirals
acquired in interleaved fashion during two spin echoes. The sequence achieved a
resolution of 1.25x1.25x2.5 mm3 in vivo on a 7T animal system, where
hyperpolarized [1-13C]pyruvate and [1-13C]lactate were
imaged alternately at a frame rate of 2 s per metabolite. Variations are
allowed in the design of the acquisition train to balance the in-plane and
through-plane resolutions. This sequence allows higher temporal resolution and
less RF depletion of the polarization than pulse sequences described previously.
