Accurate and precise dynamic contrast enhanced (DCE) measurements with reduced gadolinium toxicity by lengthening pre-injection baseline
Samuel Barnes1, Thomas Ng2, and Russell Jacobs3
1Radiology, Loma Linda University Medical Center, Loma Linda, CA, United States, 2Radiology, Brigham and Women's Hospital, Boston, MA, United States, 3Caltech, Pasadena, CA, United States
For increased patient safety it is desirable to acquire dynamic contrast enhanced (DCE) MRI data with the lowest passable Gd contrast agent (CA) dose. However, a lower CA dose generally leads to smaller signal changes and lower quality studies. Through simulations we show that lower CA doses (up to 1/2 dose) can be compensated for by extending the pre-injection baseline acquisition time to maintain similar accuracy and precision of the fitted Ktrans values.
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