Chen-Hua Wu1, Shih-Tsung Kang1, Chih-Kuang Yeh1, Wen-Shiang Chen2, and Hsu-Hsia Peng1
1Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu City, Taiwan, 2Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan
This study aims to real-time monitor inertial cavitation on microbubbles
(MBs) while transmitting focused ultrasound (FUS) with various duty cycle and
pulse repetitive frequency (PRF) by gradient echo MRI. For in vitro
experiments, with increasing duty cycle, more significant signal intensity (SI)
changes or prolonged SI drop duration were shown. For in vivo experiment, two SI
drop peaks were observed, reflecting the two IC events. In conclusion, FLASH
has been proved to be a useful technique for real-time monitoring of IC when
transmitting FUS pulses to MBs for in vitro and in vivo experiments.
