Abstract #3576

TOLD MRI Validation of Reversal of Tumor Hypoxia in Glioblastoma with a Novel Oxygen Therapeutic

Heling Zhou¹, David Wilson², Jason Lickliter³, Jeremy Ruben⁴, Natarajan Raghunand⁵, Michael Sellenger⁶, Ralph P Mason⁷, and Evan Unger^2,8

¹UT Southwestern Medical Center, Dallas, TX, United States, ²NuvOx Pharma, Tucson, AZ, United States, ³Nucleus Networks, Melbourne, Australia, ⁴William Buckland Radiotherapy Centre, Melbourne, Australia, ⁵Moffitt Cancer Center, Tampa, FL, United States, ⁶Alfred Hospital, Prahran, Australia, ⁷Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ⁸Medical Imaging, The University of Arizona, Tucson, AZ, United States

Glioblastoma multiforme (GBM) is known to be a hypoxic tumor and hypoxia adversely affects response to radiation therapy. Dodecafluoropentane emulsion (DDFPe) can improve oxygenation. Tissue oxygen level dependent (TOLD) MRI is an oxygen sensitive imaging technique which is used in this study to assess the improvement of oxygenation after administration of DDFPe. Two different doses were tested and each showed decreased T₁ indicating improved oxygenation.

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