Abstract #3572

In-Bore MRI-Guided Transperineal Prostate Biopsy using 4-DOF Needle-Guide Manipulator

Junichi Tokuda¹, Kemal Tuncali¹, Gang Li², Nirav Patel², Tamas Heffter³, Gregory S Fischer², Iulian I Iordachita⁴, Everette Clif Burdette ³, Nobuhiko Hata¹, and Clare M Tempany¹

¹Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, ²Department of Mechanical Engineering, Worcester Polytechnic Institute, Worcester, MA, United States, ³Acoustic MedSystems Inc., Savoy, IL, United States, ⁴Department Of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, United States

We present the clinical feasibility of our MRI-compatible 4-DOF needle-guide manipulator for in-bore MRI-guided transperineal prostate biopsy. Total 11 men were biopsied in a 3T MRI scanner using this manipulator. All 11 procedures were successfully performed in 102.6±24.5 minutes with targeting errors of 4.9±2.9 mm. The targeting errors were consistent with other clinical studies. Pathology results confirmed prostate cancer with Gleason score ≥ 6 in 5/6 men with previous negative TRUS biopsies, and upgraded 2/5 men on active surveillance to clinically significant cancer with Gleason score 7. In conclusion, In-bore MRI-guided prostate biopsy using the manipulator was feasible.

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