Abstract #3509

13C MRS in human calf muscles at 7T using a double tuned 4 channel 13C-4 channel 1H transceiver phased array.

Guillaume Donati¹, Eulalia Serés Roig¹, and Rolf Gruetter^1,2

¹Laboratory of Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Department of Radiology, Universities of Lausanne and Geneva, Lausanne, Geneva, Switzerland

The inherent low sensitivity of ¹³C MRS makes direct ¹³C detection challenging. Moreover, the ¹³C-¹H heteronuclear J coupling requires double tuned ¹³C-¹H coils to perform proton decoupling during ¹³C signal acquisition. High sensitivity can be achieved over a large field-of-view using array coils. We aimed to design and build a 4 channel ¹³C-4 channel ¹H transceiver phased-array coil for ¹³C-MRS studies in humans at ultra-high field. Electromagnetic performance of the coil was evaluated by FDTD simulations in calf muscles at both frequencies. Finally, ¹H-decoupled ¹³C resonance of Glycogen C₁ was successfully detected in volunteer calf muscles at 7T.

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