The Investigation of Cerebral Microstructure Changes of Pediatric Patients With Type Ⅰ Gaucher Disease Using Diffusion Kurtosis Imaging
Huiying Kang1, Ningning Zhang, Kaining Shi2, Yanqiu Lv1, Di Hu1, and Yun Peng1
1Imaging center, Beijing Children’s Hospital, Capital Medical University, Beijing, China, People's Republic of, 2Imaging Systems Clinical Science, Philips Healthcare, Beijing, China, People's Republic of
Increasing
clinical studies suggested that there are some type Ⅰ
Gaucher disease (GDⅠ) patients suffering neurological
symptom, which was originally defined as non-neuropathlogical involved. This
study recruited 38 patients and 32 normal children to investigate morphological
changes of brain in GDⅠ patients by
using Diffusion Kurtosis Imaging. Our results showed significant decreased MD
in bilateral olfactory gyrus, increased MD in right calcarine and substantia
nigra and significant increased MK in right olfactory gyrus. Our
study suggests a necessity of adjusting the opinion regarding the
CNS-involvement of GDⅠ, and DKI
analysis is a potential imaging marker in clinical studies of GDⅠ.
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