Abstract #3490

Diffusion Kurtosis Metrics as Biomarker of Fibre Maturity

Grinberg Farida^1,2, Ivan I. Maximov^1,3, Ezequiel Farrher¹, Irene Neuner^1,4,5, Eileen Oberwelland^6,7, Kerstin Konrad^5,6,8, and N. Jon Shah^1,2,5

¹Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich GmbH, Juelich, Germany, ²Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, ³Experimental Physics III, TU Dortmund University, Dortmund, Germany, ⁴Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, ⁵JARA - BRAIN - Translational Medicine, Aachen, Germany, ⁶Institute of Neuroscience and Medicine – 3, Forschungszentrum Jülich GmbH, Juelich, Germany, ⁷Translational Brain Research in Psychiatry and Neurology, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany, ⁸Child Neuropsychology Section, Department of Child and Adolescent Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany

Diffusion tensor imaging has enabled the examination of white matter connectivity and microstructural changes across the lifespan. However, the detection of subtle microstructural changes during typical brain maturation still remains challenging. Recently, diffusion kurtosis imaging has attracted much attention as an efficient method for characterising non-Gaussian water diffusion in brain tissue. Here, we tested whether diffusion kurtosis imaging can extend our knowledge of changes in brain tissue microstructure related to normal brain development. We showed that diffusion kurtosis imaging provides useful biomarkers sensitive to the level of maturity in association, projection and commissural fibres.

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