Xiaopeng Zhou1, Ken Sakaie1, Josef Debbins2, Robert Fox1, and Mark Lowe1
1Cleveland Clinic, Cleveland, OH, United States, 2Barrow Neurological Institute, Phoenix, AZ, United States
The
dependence of DTI metrics on SNR was investigated in a longitudinal multicenter
clinical trial. We presented a combined simulation and experimental analysis of
the effect of SNR on DTI measures using 27 scanners over 15 months. Although the dependence of DTI measures on SNR
is different for each type of scanner, we demonstrate the inverse relation
between mean diffusivity and SNR and FA decreasing slightly with SNR. A
sufficient SNR is essential for a reliable estimation of DTI parameters generally
and the dependence of DTI measures on SNR should be accounted for or corrected
when comparing results among scanners.
