Abstract #3428

Does reduced FOV Diffusion Weighted Imaging inherently yield lower ADC ?

Suchandrima Banerjee¹, David Aramburu-Nunez², Ramesh Paudyal², Thomas Chenevert³, Michael Boss⁴, and Amita Shukla-Dave^2,5

¹Global MR Applications & Workflow, GE Healthcare, Menlo Park, CA, United States, ²Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States, ³Department of Radiology, University of Michigan Health System, Ann Arbor, MI, United States, ⁴Applied Physics Division, National Institute of Standards and Technology, Boulder, CO, United States, ⁵Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States

The benefits of reduced field-of-view (rFOV) imaging with the single-shot echoplanar diffusion sequence such as lower distortion and better discrimination of tumor from benign tissue have been demonstrated in several anatomies. In most of these published works, lower ADC was reported using rFOV compared to the standard full FOV (fFOV) method, irrespective of the technique by which rFOV was achieved. In this work we conducted controlled experiments in 3 phantoms to avoid some of the confounding factors present in vivo and investigated if there is a systemic underestimation of ADC in rFOV DWI compared to fFOV DWI.

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