Abstract #3415

Longitudinal relationship between cerebrovascular reactivity and processing speed in young and elderly individuals

Shin-Lei Peng^1,2, Xi Chen³, Yang Li¹, Karen Rodrigue³, Yamei Cheng⁴, Denise Park³, and Hanzhang Lu¹

¹Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²China Medical University, Taichung, Taiwan, ³University of Texas at Dallas, Dallas, TX, United States, ⁴University of Texas Southwestern Medical Center, Dallas, TX, United States

Processing speed is a fundamental building block of cognition that declines reliably with age. Therefore, the goals of this study were to examine whether changes in cerebrovascular reactivity (CVR) to CO2 inhalation, a marker of cerebrovascular function, is associated with changes in processing speed. the results showed that, In elderly, but not young individuals, the rate of change in CVR over four years predicted decline in processing speed, indicating that declines in vascular brain health contribute to changes in the information processing speed in older but not young and middle-aged adults.

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