Abstract #3404

Ex-Vivo Diffusion Anisotropy of Human Brain Hemispheres

Yingjuan Wu¹, Robert J. Dawe², Arnold Moya Evia², Julie A. Schneider³, David A. Bennett³, and Konstantinos Arfanakis²

¹Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Department of Biomedical Engineering, Illinois Institute of Technology, chicago, IL, United States, ³Rush Alzheimer's Disease Center, Rush University Medical Center, chicago, IL, United States

The aims of this work were to: 1) longitudinally assess the diffusion anisotropy of various white matter regions measured with ex-vivo MRI, and 2) investigate the relationship between FA values measured in-vivo and ex-vivo on the same subjects. This work demonstrated that brain white matter diffusion anisotropy measured ex-vivo decreases with time postmortem, and that diffusion anisotropy measured ex-vivo is linearly related to the diffusion anisotropy measured in-vivo on the same subjects. Combination of ex-vivo MR diffusion anisotropy and histopathology may become an effective tool for the assessment of the neuropathologic correlates of structural brain abnormalities observed in-vivo.

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