Quantitative Susceptibility Mapping of the “Swallow tail” in Parkinson disease
Santanu Chakraborty1,2, Gerd Melkus1,2, Fahad Essbaiheen1,2,3, David A Grimes4, and Tiago Mestre4
1Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, 2Radiology, University of Ottawa, Ottawa, ON, Canada, 3King Saud University, Riyadh, Saudi Arabia, 4Neurology, The Ottawa Hospital, Ottawa, ON, Canada
Parkinson disease (PD) continues to be diagnosed based on
clinical findings. Recently, in SWI images, the loss of ‘swallow tail’ appearance
in dorsolateral substantia nigra in PD patients yielded high diagnostic
accuracy. In our study we measured susceptibility values using QSM in the
‘swallow tail’ area in seven Parkinson’s disease patients and compared to five
control subjects. The susceptibility in the swallow tail area was higher in the
PD group (0.072 vs. 0.058). This likely suggests increased
iron deposition causing a masking effect that contributes along with
dopaminergic neurons loss to the disappearance of the ‘swallow tail’ in PD
patients.
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