Wei-Tang Chang1, Fiftarina Puspitasari1, Ling-Yun Yeow1, Hui-Chien Tay1, Marta Garcia Miralles2, Katrianne Bethia Koh2, Liang-Juin Tan2, Mahmoud POULADI2,3, and Kai-Hsiang Chuang1
1SBIC, A*STAR, Singapore, Singapore, 2TLGM, A*STAR, Singapore, Singapore, 3Department of Medicine, National University of Singapore, Singapore, Singapore
Huntington disease (HD) is an incurable neurodegenerative disease. Recently, memantine (MMT) was found to be effective delaying the progression of disease phenotypes in a mouse model of HD. Here we applied resting-state fMRI to evaluate functional connectivity in HD and the MMT treatment effect and its behavioral correlates. The results of forepaw stimulation reduced evoked responses though significance was hampered by large individual variation. Interestingly, functional connectivity outside of DMN, but not within DMN, was decreased by HD. With MMT treatment, the connectivity increased in general. The FC relevant to the behavioral test also showed behavioral correlates.
