Abstract #3376

An automated pipeline for mouse brain morphometric MRI

Marco Pagani^1,2, Mario Damiano¹, Alberto Galbusera¹, Sotirios A Tsaftaris^3,4, and Alessandro Gozzi¹

¹Istituto Italiano di Tecnologia, Rovereto, Italy, ²Center for Mind and Brain Sciences, Rovereto, Italy, ³IMT - Institute for Advanced Studies, Lucca, Italy, ⁴Institute of Digital Communications, School of Engineering, The University of Edinburgh, Edinburgh, United Kingdom

We provide a detailed description of registration-based procedures for voxel based morphometry, cortical thickness estimation and automated anatomical labelling of the mouse brain. To illustrate our procedures, we described their application to quantify morphological differences in two inbred mouse strains characterised by different social behaviour. We show that our approach can reliably detect both focal and large scale gray matter alterations using complementary readouts. The operational workflows described here are expected to help the implementation of rodent morphoanatomical methods by non-expert users, and promote the use of these tools across the preclinical neuroimaging community.

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