Abstract #3360

Robust fiber crossing invariant analysis of white matter microstructure in acute mild traumatic brain injury

Mehrbod Mohammadian^1,2, Timo Roine³, Jussi Hirvonen^2,4, Timo Kurki², and Olli Tenovuo^1,2

¹Department of Rehabilitation and Brain Trauma, Turku University Hospital, Turku, Finland, ²Department of Clinical Medicine, University of Turku, Turku, Finland, ³iMinds-Vision Lab, Department of Physics, University of Antwerp, Antwerp, Belgium, ⁴Department of Radiology, Turku University Hospital, Turku, Finland

We used a robust diffusion MRI approach to analyze global microstructural abnormalities in mild traumatic brain injury (mTBI) without confounding effects of complex fiber configurations. Microstructural properties of white matter skeleton were investigated, but only voxels with a single fiber orientation detected with constrained spherical deconvolution were included. In addition, whole-brain fiber tractograms were investigated. We studied 107 patients with mTBI and 28 age-matched control subjects. We found that fractional anisotropy was significantly decreased in mTBI, while mean diffusivity and radial diffusivity were increased. These differences were more significant when the analysis was restricted to single-fiber voxels.

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