Acute white matter changes within 24 hours and at 8 days following sport-related concussion: a diffusion tensor and diffusion kurtosis imaging study
Daniel V. Olson1, Melissa A. Lancaster2,3, Michael A. McCrea2,3, and L. Tugan Muftuler2
1Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, 2Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, 3Neurology, Medical College of Wisconsin, Milwaukee, WI, United States
The aim of this study was to characterize acute white matter changes within 24 hours and at 8 days following sport-related concussion in a group of young adult athletes. Both diffusion tensor and diffusion kurtosis tensor parameters were compared between concussed athletes and controls. The concussed group demonstrated widespread decrease in mean, axial, and radial diffusivity and increased axial kurtosis compared to the controls. Although diffusion effects became more extensive between the two time points, clinical measure differences between groups were nonsignificant at the 8-day follow-up. These findings may have significant implications for the clinical management of sport-related concussions.
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