Abstract #3356

Hybrid Diffusion Imaging to Detect Acute White Matter Injury after Mild TBI

Sourajit Mitra Mustafi¹, Chandana Kodiweera², Laura A. Flashman³, Thomas W. McAllister⁴, and Yu-Chien Wu¹

¹Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ²Department of Psychological and Brain Sciences, Dartmouth College, Dartmouth, NH, United States, ³Department of Psychiatry, Dartmouth Hitchcock Medical Center and New Hampshire Hospital, Lebanon, NH, United States, ⁴Department of Psychiatry, Indian University School of medicine, Indianapolis, IN, United States

In the present study we used multi-shell Hybrid Diffusion Imaging (HYDI) to study white matter changes in the acute stage of mild traumatic brain injury (mTBI). Nineteen mTBI patients and 23 trauma-controlled subjects were recruited and studied within 1 month of injury. Non-parametric diffusion analysis, q-space imaging as well as parametric analyses including conventional DTI and novel neurite orientation dispersion and density imaging (NODDI) were used to analyze the HYDI data. Only intra-axonal volume fraction of the NODDI model showed significant and diffuse decrease in white matter of the mTBI patients.

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