Jolanda M Spijkerman1, Jill B de Vis1, Esben T Petersen2, Jeroen Hendrikse1, and Jaco J M Zwanenburg1
1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Centre for Functional and Diagnostic Imaging and Research, Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark
The
oxygen tension in CSF and tissue is coupled, but may be easier to measure in
CSF. This work investigated the effect of O2 administration on the T2
of CSF. In five subjects, T2s were mapped in the lateral ventricles
and the peripheral CSF during administration of a hyperoxic gas mixture
(end-tidal O2 level: 500mmHg). In the lateral ventricles no T2
change was observed, in the periphery a significant T2 reduction was
found under O2 administration (T2=1.54s) compared to
baseline (T2=1.61s), showing the feasibility to use CSF relaxation
parameter mapping to detect oxygen tension changes.
