Alberto Merola1, Esther AH Warnert1, Michael A Germuska1, Sharmila Khot1,2, Daniel Helme2, Lewys Richmond2, Kevin Murphy1, and Richard G Wise1
1CUBRIC, Cardiff University, Cardiff, United Kingdom, 2Department of Anesthesia and Intensive Care Medicine, Cardiff University, Cardiff, United Kingdom
The acute effects of caffeine on haemodynamics are not well
characterized across the brain with MRI. We aim at measuring these in a
double-blind, crossover, placebo-controlled study on sixteen healthy,
moderate caffeine consumers using mTI PASL acquisitions and a two-compartment
ASL model. Results show spatial variations in the CBF and TAT response across
grey matter at different levels of resolution (grey matter, ROI and voxel),
with the latter presenting mixed directions. Moreover we demonstrate that
great attention must be paid to physiological assumptions when modelling ASL
data to estimate CBF in studies on drugs that affect brain haemodynamics.
