Abstract #3310

A Novel Diffusion Tensor Imaging Strategy for Delineating the Neuroanatomical Boundaries of the Amygdala

Andre Obenaus^1,2, Eli Kinney-Lang^1,3, Duke Shereen⁴, Ana Solodkin^3,4, and Tallie Z Baram^2,3

¹Pediatrics, Loma Linda University, Loma Linda, CA, United States, ²Pediatrics, University of California, Irvine, Irvine, CA, United States, ³Anatomy/Neurobiology, University of California, Irvine, Irvine, CA, United States, ⁴Neurology, University of California, Irvine, Irvine, CA, United States

The amygdaloid complex, including the basolateral nucleus (BLA) are critically important in mediating emotional and adaptive responses to stress. However, lack of contrast between the BLA and the surrounding gray matter (GM) has hampered routine imaging. We report a novel DTI paradigm to identify the BLA in the rodent brain. We derived BLA volumes and confirmed these with histological measures. Our approach can be used to study the morphological and functional consequences of emerging neuropsychiatric diseases, both in experimental and clinical studies.

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