Shelley HuaLei Zhang1, Jr-Yuan George Chiou1, Robert Vincent Mulkern1, Pelin Aksit Ciris2, Stephan Maier1, and Lawrence Panych1
1Radiology, Brigham and Women's Hospital, Boston, MA, United States, 2Department of Biomedical Engineering, Akdeniz University, Antalya, Turkey
Magnetic resonance spectroscopic imaging (MRSI) technique
is often plagued by signal contamination (e.g. from fat) from outside the
tissue of interest, particularly near organ boundaries. The goal is to
demonstrate and validate in phantoms and healthy volunteers a spatial
localization technique that features localized signal excitation and therefore eliminates
the need for post-processing filtering. Here we demonstrated superior PSF’s at prostate-relevant
metabolic peaks for a 2D Gaussian-based PSF-Choice encoding scheme. The
reduction of contamination from signals in surrounding tissue was further
demonstrated in an in-vitro phantom. The feasibility of the method was demonstrated
in a small group of prostate MRSI studies with normal volunteers.
