Abstract #3274

DEVELOPMENT AND MULTI-CENTER VALIDATION OF A NOVEL WATER-FAT-IRON PHANTOM FOR JOINT FAT AND IRON QUANTIFICATION

Samir D. Sharma¹, Diego Hernando¹, Takeshi Yokoo², Mustafa R. Bashir^3,4, Jean Shaffer^3,4, Qing Yuan², Stefan Ruschke⁵, Dimitrios C. Karampinos⁵, Jean H. Brittain¹, and Scott B. Reeder^1,6

¹Radiology, University of Wisconsin - Madison, Madison, WI, United States, ²Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ³Radiology, Duke University, Durham, NC, United States, ⁴Center for Advanced Magnetic Resonance Development, Duke University, Durham, NC, United States, ⁵Diagnostic and Interventional Radiology, Technische Universität München, Munich, Germany, ⁶Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

The need for rapid and non-invasive assessment of fat and iron deposition has become increasingly important given the high prevalence of obesity and obesity-related comorbidities as well as the need for monitoring chelation treatment in patients with iron overload. Recent advances in gradient-echo imaging have enabled the simultaneous quantification of fat and iron concentrations throughout the body. To ensure fidelity of these quantitative techniques, validation studies must be performed, ideally with initial testing in phantoms. In this work, we report on the development of a water-fat-iron MRI phantom that exhibits single-R2* decay, with controllable proton-density fat fraction (PDFF) and iron concentration. The purpose of this work is: 1) to describe the development of the water-fat-iron phantom, and 2) to assess the multi-center, multi-vendor reproducibility of joint fat and iron quantification using this phantom.

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