Mahon L Maguire1, Mala Rohling2, Megan Masters2, Debra McAndrew1, Paul Riley2, and Jurgen E Schneider1
1Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, 2Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom
The neonatal mouse heart has been reported to regenerate
following myocardial injury during the first days of life. Research into this
regenerative capability is being actively pursued for translation into the
clinic. This study presents cardiac cine
imaging of one-day old mice using retrospectively gated, accelerated MR imaging
with recovery. Images were acquired
with 78x78x500 μm resolution. Left
ventricular functional parameters were derived from the images and are
presented. This proof of concept study
demonstrates that cardiac functional MR imaging with recovery in newborn mice
is practical. It also allows the
investigation of myocardial regeneration during the first days of life.
