Abstract #3128

Peak Filling Rates assessed by Cardiac Magnetic Resonance Imaging indicate Diastolic Dysfunction from Myocardial Iron Toxicity

Jin Yamamura¹, Sarah Keller¹, Roland Fischer^2,3, Regine Grosse⁴, Gregory Kurio³, Gunnar Lund¹, Joachim Graessner⁵, Gerhard Adam¹, and Bjoern Schoennagel¹

¹Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ²Biochemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ³Department of Radiology, UCSF Benioff Children's Hospital Oakland, Oakland, CA, United States, ⁴Department of Pediatric Hematology/Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁵Siemens Healthcare, Hamburg, Germany

The diastolic peak filling rate ratio (PFRR) is a sensitive marker to indicate diastolic dysfunction from myocardial iron toxicity in patients with systemic iron overload disease. Precise assessment of the PFRR by CMR requires a volumetric approach with exclusion of trabeculae and papillary muscles from the LV cavity. The PFRR assessed by CMR may be a valuable parameter for the screening and monitoring of myocardial iron toxicity due to iron deposition in patients with preserved systolic function.

This abstract and the presentation materials are available to members only; a login is required.

Join Here