Abstract #3109

In Vivo Cardiac DTI on a 3T Clinical Scanner: An Optimized M2 Approach

Christopher Nguyen¹, Zhaoyang Fan¹, Yibin Xie¹, Jianing Pang¹, Xiaoming Bi², Peter Speier³, Jon Kobashigawa⁴, and Debiao Li^1,5

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²MR R&D, Siemens Healthcare, Los Angeles, CA, United States, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁵Bioengineering, University of California Los Angeles, Los Angeles, CA, United States

Optimized second order motion compensated (M2) diffusion tensor prepared cardiac magnetic resonance (DT-CMR) was applied in healthy volunteers and heart failure patients at 3T. The pulse sequence design focused on B1 robustness at high main field. In healthy volunteers, the proposed M2 DT-CMR was compared to zero order (M0) and first order (M1) motion compensations. In addition, heart rate dependency of the proposed M2 DT-CMR was explored with contextual comparison to M0 and M1. M2 DT-CMR was the only technique capable of application in heart failure patients without bulk motion artifacts.

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