Abstract #3101

Assessment of pharmacotherapy effects on APP/PS1 mice brain by Diffusion Spectrum Imaging

Chih-Hsien Tseng^1,2, Yu-Jen Chen¹, and Wen-Yih Isaac Tseng^1,2,3,4

¹Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ²Institute of Biomedical Engineering, National Taiwan University College of Medicine, Taipei, Taiwan, ³Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan, ⁴Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

To determine the effects of a novel neuroprotective drug on white matter integrity in Alzheimer’s disease (AD), generalized fractional anisotropy (GFA) was assessed in mice brains using diffusion spectrum imaging (DSI). The mice included 5 AD mice without medication, 4 AD mice with medication, and 5 control mice. Comparing with the control mice, the AD mice without medication showed significantly increased GFA in the hippocampus and thalamus, whereas the AD mice with medication showed no significant difference. Our findings imply that DSI can be used to monitor the drug effects in AD mice.

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