Abstract #3040

Voxel Level Comparison of Two Anomalous Diffusion Models: Continuous-Time Random-Walk Model versus Fractional Motion Model

Muge Karaman¹, Ying Xiong^1,2, Kejia Cai^1,3, and X. Joe Zhou^1,4

¹Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, ²Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, People's Republic of, ³Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States, ⁴Departments of Radiology, Neurosurgery, and Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

Over the past decades, several non-Gaussian diffusion models have been developed to reveal the underlying structures of the complex and heterogeneous tissue by measuring the anomalous diffusion behavior. Within these, continuous-time random-walk (CTRW) and fractional motion (FM) models have actively been studied by several groups to compare them at cellular or molecular level. In this study, we provide a comparison between the CTRW and FM models on human brain in vivo at the voxel level using high b-value diffusion MRI. It was observed that all CTRW and FM parameters exhibit characteristic contrasts, reflecting different aspects of the complex diffusion process.

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