Recent method developments have improved the reconstruction of fibre orientation distributions in white matter by incorporating partial voluming with isotropic grey matter and CSF. Yet, their use is limited to multi-shell data. Here, we present a generalization of convexity-constrained non-negative spherical factorization to multi-modal data, and illustrate its use for decomposing single-shell diffusion-weighted data and T1 anatomical data in three tissue components. Results show that we can effectively reconstruct fibre orientation distributions and separate isotropic volume fractions of grey matter and CSF in single-shell data, even at low b-values.
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