Reliable estimation of Diffusional kurtosis in the skeletal muscle needs perfusion correction.
Alberto De Luca1,2,3, Alessandra Bertoldo1, and Martijn Froeling3
1Department of Information Engineering, University of Padova, Padova, Italy, 2Neuroimaging Lab, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini (LC), Italy, 3Department of Radiology, University Medical Center, Utrecht, Netherlands
Perfusion is
known to affect the estimation of Diffusion Tensor Imaging (DTI) measures on
the skeletal muscle. However, no previous works evaluated its effects on kurtosis
estimation. Therefore, in this study we investigated the influence of perfusion
on kurtosis. Synthetic signals for different perfusion levels with and without isotropic
kurtosis were generated and then fitted with and without taking IVIM into consideration.
Results showed that IVIM correction was essential to estimate non-biased values
of kurtosis in case of increased perfusion. Real data showed that the
simultaneous estimation of kurtosis and IVIM is robust and feasible.
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