Abstract #3034

Joint reconstruction of high-SNR multiple b-values diffusion-weighted images using projection onto convex sets based multiplexed sensitivity-encoding (POCSMUSE)

Hing-Chiu Chang^1,2, Mei-Lan Chu², and Nan-Kuei Chen²

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, United States

Intra-voxel incoherent motion (IVIM) MRI utilizes diffusion-weighted echo-planar imaging (DW-EPI) technique to acquire a set of image data with multiple b-values. The major limitation of IVIM is due to long acquisition time for multiple b-values that can lower the feasibility of clinical use, especially it requires multiple averaging of high-b value to compensate SNR loss. In this study, we propose a joint reconstruction framework of POCSMUSE algorithm, to simultaneously reconstruct under-sampled multi-b interleaved DW-EPI data with reduced noise amplification.

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