The importance of b-values selection and the precision of diffusion kurtosis estimation by the conventional schemes
Andrey Chuhutin1, Noam Shemesh2, Brian Hansen1, and Sune Nørhøj Jespersen1,3
1CFIN, Aarhus University, Aarhus, Denmark, 2Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal, 3Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark
In DKI imaging studies, a wide range of
different gradient strengths is used, which is known to affect the
estimated kurtosis. Being driven by a need to assess the validity
of the DKI expression and the accuracy of the estimated parameters
as a function of b-value we both evaluated the variability of the
kurtosis parameter for the in vivo and ex vivo data for different
fitting techniques and studied the error in a mean kurtosis
parameter with respect to the ground truth. The results and
conclusions suggest circumspection while preferring a specific
technique.
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