Abstract #3013

Assessment of Diffusion Time Dependence of Diffusion Kurtosis in Rat Spinal Cord

Nathaniel D Kelm^1,2, Kevin D Harkins², and Mark D Does^1,2,3,4

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, TN, United States, ⁴Electrical Engineering, Vanderbilt University, Nashville, TN, United States

Diffusion kurtosis imaging (DKI) is an extension of DTI with the ability to provide additional information about tissue microstructure. To evaluate the diffusion time dependence of diffusion kurtosis, kurtosis is measured perpendicular to white matter tracts in rat spinal cord for diffusion times ranging from 12 to 100 ms. In this study, kurtosis increased as a function of diffusion time in white matter, yet decreased in gray matter. Assessing the change in diffusion kurtosis across diffusion time could potentially inform upon the underlying white matter microstructure.

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