Abstract #3004

Cardiac in vivo T1-Mapping with Novel Reactive Oxygen Species Sensing Agent Specifically Detects Cardiac Oxidative Stress in Doxorubicin-treated Rats

Ronald J Beyers¹, Meng Yu², Dean Schwartz³, Nouha Salibi^1,4, Christian Goldsmith⁵, and Thomas Denney¹

¹MRI Research Center, Auburn University, Auburn University, AL, United States, ²Chemistry & Biochemistry, Auburn University, Auburn University, AL, United States, ³Anatomy, Physiology and Pharmacology, Auburn University, Auburn University, AL, United States, ⁴MR R&D, Siemens Healthcare, Malvern, PA, United States, ⁵Chemistry and Biochemistry, Auburn University, Auburn University, AL, United States

Pathological cardiac oxidative stress causes cardiac dysfunction and possible cardiac failure. We developed a novel reactive oxygen species sensing T1 agent (H4qpt2) and applied it with in vivo cardiac T1 mapping MRI at 7T in a doxorubicin-treated (Dox) rat model. Cardiac T1 mapping with H4qpt2 specifically detected significantly shortened myocardial T1 in Dox rats while no change in T1 occurred in skeletal muscle or control rats with H4qpt2. This new H4qpt2 agent combined with cardiac or non-cardiac T1 mapping may advance the early detection of oxidative stress in multiple pathologies and promote their early treatment.

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