Correlation of Pre –Treatment Volumetric Apparent Diffusion Coefficient Histogram Analysis of Diffusion Weighted MRI in Rectal Cancer with Post ChemoRadiation Treatment Response and Clinical Outcomes.
Kartik Jhaveri1, Vijay Chidambaram2, James Brierley1, Bernard Cummings1,3, Rajesh Bhayana1, Ravi Menezes1, Erin Kennedy4, and Richard Kirsch4
1UHN,university of Toronto, Toronto, ON, Canada, 2Royal Liverpool Hospital, Liverpool, United Kingdom, 3Toronto, Canada, 4Mt.Sinai Hospital,University of Toronto, Toronto, Canada
Rectal cancer patients treated
with preoperative chemoradiation therapy with complete treatment response can
be considered for individualised therapies such as ‘wait and watch’ avoiding
surgery. However this currently can only be definitely identified by
postoperative histopathology. Diffusion weighted-MRI
has been well correlated to tumor biology and treatment response. Volumetric
ADC histogram analysis eliminates errors resulting from tumor heterogeneity and
variable diffusivities by including the tumor volume and could provide promise
for prediction of treatment response and clinical outcomes,thereby providing
means for individualised therapy.
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