Abstract #2951

Noninvasive MR diffusion and perfusion analysis of liver fibrosis using comprehensive parameters

qing li¹, shuangshuang xie¹, yu zhang², wenjing hou¹, yue cheng¹, and wen shen¹

¹Radiology, Tianjin First Center Hospital, Tianjin, China, People's Republic of, ²Philips healthcare, Beijing, China, People's Republic of

This study investigated the value of multi-parametric analysis using MR IVIM, BOLD MRI and DKI for the diagnosis of liver fibrosis. Eight patients with clinically diagnosed liver fibrosis and thirteen healthy control subjects were scanned with DKI, IVIM, BOLD. IVIM derived D*, D, f, DKI derived MD, K value and BOLD derived R2* were compared between the two groups. Our results showed D*, D, f, MD decreased, R2* and K value increased in patients with liver fibrosis, but only D* and D demonstrated significant difference (P<0.05). We therefore conclude D* and D could be useful in the diagnosis of liver fibrosis.

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