Abstract #2947

Liver IVIM MR imaging: improved reproducibility of pseudo-diffusion coefficient D* via proper signal modeling

Shih-Han Hung¹, Meng-Chieh Liao¹, Cheng-Ping Chien¹, Wen-Chau Wu², and Hsiao-Wen Chung³

¹Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ²Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, ³Electrical Engineering, National Taiwan University, Taipei, Taiwan

A new scheme was proposed to analyze intravoxel ihcoherent motion MR imaging data of the liver. The method integrated the combined use of single- and bi-exponential signal decaying models to deal with regions with absence of prominent vasculature, and the removal of data obtained at b-values less than 15s/mm² to avoid contamination from large vessels. Results from ten healthy subjects scanned twice at 3T showed substantially improved reproducibility in the pseudo-diffusion coefficient D*, while those of the true diffusion coefficient and the profusion fraction were unaltered. Using our scheme the estimated D* mostly fall within 38 to 85x10^-3 mm²/s.

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