Abstract #2935

Quantitative assessment and follow-up of hepatocellular carcinoma in rat livers using clinical 3T MRI.

Lorenzo A Orci¹, Graziano Oldani¹, Stephanie Lacotte¹, Florence Slits¹, Iris Friedli², Wolfgang Wirth³, Jean-Paul Vallée², Christian Toso¹, and Lindsey Alexandra Crowe²

¹Division of Abdominal and Transplantation Surgery, Hepato-pancreato-biliary Centre, Department of Surgery, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland, ²Division of Radiology, Geneva University Hospital and Faculty of Medicine, Geneva, Switzerland, ³Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria

In vivo liver cancer research commonly uses rodent models of liver tumor growth. One of the limitations of such models is the lack of accurate and reproducible endpoints for dynamic assessment tumor nodules. We used 3T clinical MRI to quantify tumor volume over time and correlate to gold standard histological volumes and blood levels of α-fetoprotein in two rat orthotopic models of hepatocellular carcinoma (HCC). Combination of 3D isotropic gradient echo for accurate volume and T2 for contrast provided appealing correlation. We have developed a 3D volume quantification method that enables follow-up and analysis of complex tumor morphology.

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