Abstract #2929

Improved fitting of 129Xe spectroscopy identifies three dissolved-phase resonances in the human lung

Scott H. Robertson^1,2, Elianna A. Bier^1,2, Rohan S. Virgincar^1,3, and Bastiaan Driehuys^1,2,3,4

¹Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, ²Medical Physics Graduate Program, Duke University, Durham, NC, United States, ³Department of Biomedical Engineering, Duke University, Durham, NC, United States, ⁴Department of Radiology, Duke University Medical Center, Durham, NC, United States

Hyperpolarized ¹²⁹Xe experiences chemical shifts between the lung airspaces, interstitium, and capillary beds, enabling functional information to be directly probed. However, in order to realize the potential of these chemical shifts, the spectrum must be carefully decomposed. Previous methods have assumed only two dissolved-phase resonances exist in the human lung and have used inconsistent 0 ppm reference frequencies. Here we present novel non-linear fitting of complex exponentially decaying FIDs and demonstrate that the dissolved phase signal can be robustly decomposed into three dissolved-phase resonances. We present updated frequencies and widths using and appropriately adjusted 0 ppm reference value.

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