Longitudinal Assessment of Pulmonary Permeability in a Mouse Model of Lung Fibrosis
Iliyana P Atanasova1, Pauline Desogere1, Clemens K Probst2, Nicholas Rotile1, Andrew M Tager2, and Peter Caravan1
1A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA, United States
Idiopathic pulmonary fibrosis is a fatal condition without
effective treatment. Given evidence that vascular leak promotes fibrosis, we assessed
whether pulmonary leak could be quantified using dynamic MRI and an intravascular
tracer. In a mouse model we observed that permeability to albumin rose sharply on day 3
after insult, returned to baseline by day 5 and increased moderately between
days 5-13. To our knowledge this is the first report of the time course of vascular
leak in pulmonary fibrosis. The proposed method could be useful for studying
the role of lung permeability in fibrosis and for monitoring of treatment
response.
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