Abstract #2910

Improvement of in vivo glucoCEST imaging in rat brain using inverse z-spectrum analytical scheme at 7.0 T

Ping-Huei Tsai^1,2,3, Hua-Shan Liu^4,5, Fei-Ting Hsu⁶, Yu-Chieh Kao³, Chia-Feng Lu³, Li-Chun Hsieh², Pen-Yuan Liao², Hsiao-Wen Chung⁷, and Cheng-Yu Chen^1,2,3

¹Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ²Department of Medical Imaging, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, ³Translational Imaging Research Center, Taipei Medical University, Taipei, Taiwan, ⁴Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan, ⁵Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, ⁶Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan, ⁷Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan

GlucoCEST have been proposed to assess the discrepant concentrations of glucose in vitro. However, it is still a challenge to obtain accurate signals from glucose in vivo. Our preliminary finding demonstrated that the proposed analytical scheme provides an alternative to extract glucose profile and could be more robust to the field inhomogeneity, which may be helpful in further implementation in disease models.

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