Abstract #2905

Use of Yb-HPDO3A probe for CEST-MRI pH mapping in glioblastoma mouse models

Giuseppe Ferrauto¹, Michel Sarraf², Enza Di Gregorio¹, Vincent Auboiroux³, Ulysse Gimenez², François Berger², Silvio Aime¹, and Hana Lahrech²

¹Dept of Molecular Biotechnologies & Health Sciences, University of TORINO (IT), Torino, Italy, ²CLINATEC-CEA-INSERM UA01 – CHU –UJF Grenoble (FR), Grenoble, France, ³CLINATEC-CEA Grenoble (FR), Grenoble, France

MRI maps of extracellular/extravascular pH distribution in glioblastoma mouse model (U87 cells) have been obtained by administrating YbHPDO3A CEST probe. This molecule has potential in a clinical setting as it displays analogue properties (stability and in vivo pharmacokinetic) of its analogue clinically approved Gd-HPDO3A (ProHance). Furthermore, glioblastoma pH maps have been correlated with histology (H/E, Hif-1a and Ki-67 staining). The assessment of glioblastoma pHe could be used to monitor tumor development and to target acidic tumor regions using innovative responsive pH therapies.

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