Dynamic susceptibility
contrast MRI (DSC MRI) is widely used for cerebral blood flow (CBF) measurement
for diseases, such as stroke and cancer.1-2 Fundamental assumption
of DSC-MRI based CBF measurement is that contrast agent is non-leaking with
intact blood brain barrier (BBB).3 Here, we investigate the effect
of BBB disruption on the CBF measurement, especially for stroke model utilizing
serial dual acquisitions using DOTAREM and SPION. As SPION remains as
intravascular agent, while DOTAREM becomes extravasating agent with BBB
disruption, dual CBF acquisitions with both agents provide quantitative way to
characterize the effect of BBB disruption on CBF measurements with DSC-MRI.
