Diana Khabipova1,2, Rita Gil2, Marcel Zwiers2, and José Pedro Marques2
1CIBM-AIT, EPFL, Lausanne, Switzerland, 2Centre for Cognitive Neuroimaging, Donders Institute, Nijmegen, Netherlands
Quantitative susceptibility
mapping (QSM) has been shown to provide quantitative measures of iron
concentration in deep gray matter structures. In white matter, QSM is affected
not only by local susceptibility but also by the local organized
microstructure of axons and its myelin coating where reduced water signal
exists. Recently, the anisotropic effect of myelin susceptibility was shown to
be minor compared to the effect of its compartmentalization. In this work, the
Lorentzian correction was, for the first time, implemented in a COSMOS like QSM
reconstruction. The correction does not affect deep gray matter structure
values, but creates QSM maps of isotropic susceptibility and maps of the
susceptibility of cylindrically organized inclusion spaces.
