WHOLE-BODY QUANTITATIVE SUSCEPTIBILITY MAPPING IN HEALTHY SUBJECTS AND IN PATIENTS WITH IRON OVERLOAD
Samir D. Sharma1, Jens-Peter Kühn2, Marie-Luise Kromrey2, Scott B. Reeder1,3, and Diego Hernando1
1Radiology, University of Wisconsin - Madison, Madison, WI, United States, 2Experimental Radiology, Greifswald University, Greifswald, Germany, 3Medical Physics, University of Wisconsin-Madison, Madison, WI, United States
Magnetic
susceptibility is a fundamental property of all tissues. The presence of biomaterials
(e.g. iron, gadolinium) changes the susceptibility of the tissue in a direct
and well-understood manner, allowing quantification of biomaterial concentration. Quantitative
susceptibility mapping (QSM) techniques have been developed, largely to
investigate iron and calcium deposits in the brain. The development and
application of whole-body QSM may enable improved characterization and
quantification of tissue pathophysiology based on a fundamental property of
tissue. Thus, the purpose of this work was to develop and demonstrate the
feasibility of whole-body QSM in healthy subjects and in patients with
suspected iron overload.
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