Magnetic Saturation and Field Dependency on Magnetic Susceptibility of Ferumoxytol
Jean-Christophe Brisset1, Pippa Storey1, Saifeng Liu2, E. Mark Haacke3, and Yulin Ge1
1Radiology, New York University School of Medicine, New York, NY, United States, 2The MRI Institute for Biomedical Research, Waterloo, ON, Canada, 3Radiology, Wayne State University, Detroit, MI, United States
The
magnetization of diamagnetic and paramagnetic materials is proportional to the
strength of the applied magnetic field, with a constant of proportionality (χ)
known as the magnetic susceptibility. While the magnetization of ferromagnetic
and superparamagnetic materials is much higher than that of diamagnetic and
paramagnetic materials, it becomes saturated in strong magnetic fields. We show
that the magnetization of USPIO agents such as Ferumoxytol saturates at around
1.5T. This introduces a perceived inverse correlation between apparent susceptibility
and field strength. By contrast, the magnetization of GdDTPA is proportional to
field strength up to 7T, as expected for a paramagnetic material.
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