Pinar Senay Özbay1,2, Cristina Rossi1, Sonja Stieb3, Oliver Riesterer3, Andreas Boss1, Klaas Paul Pruessmann2, and Daniel Nanz1
1Department of Radiology, University Hospital Zurich, Zurich, Switzerland, 2Institute of Biomedical Engineering, ETH Zurich, Zurich, Switzerland, 3Department of Radio-Oncology, University Hospital Zürich, Zurich, Switzerland
Glioblastoma
multiforme and anaplastic astrocytoma are aggressive
brain tumors which can form large heterogeneous lesions, parts of which respond
with varying sensitivity to radiotherapy. The long-term goal of the current
study is to characterize the oxygenation state of tumors or parts of
heterogeneous large tumors by quantitative-susceptibility-mapping, under
hyperoxic respiratory challenge, and yield valuable information, e.g., for an
improved dose shaping, which may lead to an improved therapy outcome. The
preliminary results suggest that QSM may indeed be capable of differentiating
the response of well vascularized tumor-tissue volumes to respiratory-induced
hypoxia from the response of likely necrotic and edematous volumes.
