Abstract #2818

Rapid Multislice T1 Mapping of Contrast-Enhanced Mouse Tumor Using Saturation Recovery Look-Locker Method with Spiral Readout

Yuchi Liu¹, Zheng Han¹, Kai Jiang², Yun Jiang¹, Yajuan Li¹, Zheng-Rong Lu¹, and Xin Yu^1,3,4,5

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States, ³Radiology, Case Western Reserve University, Cleveland, OH, United States, ⁴Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States, ⁵Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States

In this study, a rapid multislice saturation-recovery Look-Locker (MSRLL) T₁ mapping method with spiral readout was developed for the application on tissues with long T₁ value, such as tumor. This method was validated in vitro and evaluated in a dynamic contrast-enhanced MRI (DCE-MRI) study on mouse tumor. The spiral MSRLL method showed a strong agreement with Cartesian method, and achieved temporal resolution of 2 min 40s with a voxel size of 0.23×0.23×1 mm³ in vivo.

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