Erwin Krikken1, Wybe J.M. van der Kemp1, Hanneke W.M. van Laarhoven2, Dennis W.J. Klomp1, and Jannie P. Wijnen1
1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Medical Oncology, Academic Medical Center Amsterdam, Amsterdam, Netherlands
Neoadjuvant chemotherapy
plays an important role in the treatment of breast cancer patients. During
chemotherapy, the phospholipid metabolism changes which can be measured by 31P-MRS
at 7 tesla. Eight patients were examined, using the AMESING sequence to receive
metabolic signals in the tumor. The 31P-MRS data were analyzed on
group level, which enables the detection of changes the levels of phospholipid
metabolites in an early stage of the treatment, directly after the first cycle
of chemotherapy.
