Dattesh D Shanbhag1, Parita Sanghani1, Reem Bedair 2, Venkata Veerendranadh Chebrolu1, Sandeep N Gupta3, Scott Reid 4, Fiona Gilbert 2, Andrew Patterson 2, Rakesh Mullick1, and Martin Graves2
1GE Global Research, Bangalore, India, 2University of Cambridge, Cambridge, United Kingdom, 3GE Global Research, Niskayuna, NY, United States, 4GE Healthcare, Leeds, United Kingdom
In this work,
we investigated the impact of incorporating T1 and/or B1 maps on PK parameters
in breast cancer patients and impact of these PK maps on assessing therapy
response in longitudinal data. DCE-MRI PK parameters in six breast cancer patients was investigated with four different processing schemes comprising combinations of T1 and B1 map with DCE and its trend assessed in longitudinal data . We
demonstrate that in breast tumor imaging, a DCE protocol incorporating T1 and
B1 mapping can be more reliable in reflecting tumor heterogeneity and
predicting therapy response longitudinally.
